RHBDF2 - Inactive rhomboid protein 2 - human protein (Function)
 
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RHBDF2 »  Inactive rhomboid protein 2  (iRhom2)
 
Protein also known as:  Rhomboid veinlet-like protein 6.
Gene name:  RHBDF2
Family name: Peptidase S54
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Growth factor bindingdefinition[GO:0019838]  
  • IEAUniProtKB KW
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
GO biological process 
Negative regulation of protein secretiondefinition[GO:0050709]  
  • ISSOrtholog Curator
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
Proteolysisdefinition[GO:0006508] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
 
More information is available from:
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RHBDF2
GenomeRNAi: 79651
PRO: PR:Q6PJF5