RHBDF2 - Inactive rhomboid protein 2 - human protein (Function)
 
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RHBDF2 »  Inactive rhomboid protein 2  (iRhom2)
 
Protein also known as:  Rhomboid veinlet-like protein 6.
Gene name:  RHBDF2
Family name: Peptidase S54
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).  
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  • UniProtKB
GO molecular function 
Growth factor bindingdefinition[GO:0019838]  
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  • UniProtKB KW
Not  Serine-type endopeptidase activitydefinition[GO:0004252]  
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  • RefGenome
GO biological process 
Negative regulation of protein secretiondefinition[GO:0050709]  
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  • Ortholog Curator
Not  Protein processingdefinition[GO:0016485]  
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  • RefGenome
Protein transportdefinition[GO:0015031]  
1
  • UniProtKB KW
Regulation of epidermal growth factor receptor signaling pathwaydefinition[GO:0042058]  
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  • RefGenome
Regulation of protein secretiondefinition[GO:0050708]  
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  • RefGenome
Enzymatic activity 
 
More information is available from:
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RHBDF2
GenomeRNAi: 79651
PRO: PR:Q6PJF5