BRAT1 - BRCA1-associated ATM activator 1 - human protein (Function)
 
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Protein
Gene
References

 
BRAT1 »  BRCA1-associated ATM activator 1
 
Protein also known as:  BRCA1-associated protein required for ATM activation protein 1.
Gene name:  BRAT1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed16452482, PubMed22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed25657994).  
5
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
4
  • UniProtKB
  • IntAct
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB
Cell growthdefinition[GO:0016049]  
1
  • UniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • UniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • UniProtKB
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • UniProtKB
Glucose metabolic processdefinition[GO:0006006]  
1
  • UniProtKB
Mitochondrion localizationdefinition[GO:0051646]  
1
  • UniProtKB
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • UniProtKB
Response to ionizing radiationdefinition[GO:0010212]  
1
  • UniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 221927
PRO: PR:Q6PJG6