ATAD2 - ATPase family AAA domain-containing protein 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ATAD2 »  ATPase family AAA domain-containing protein 2   [ EC 3.6.1.3 ]
 
Protein also known as:  AAA nuclear coregulator cancer-associated protein (ANCCA).
Gene name:  ATAD2
Family name: AAA ATPase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 43 2
GENE REF ISO

Function

 show evidences
Overview 
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activitydefinition[GO:0016887]  
1
  • IDAUniProtKB
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.1.3: ATP + H(2)O ADP + phosphate.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 29028
PRO: PR:Q6PL18