ATAD2 - ATPase family AAA domain-containing protein 2 - human protein (Function)
 
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ATAD2 »  ATPase family AAA domain-containing protein 2   [ EC 3.6.1.3 ]
 
Protein also known as:  AAA nuclear coregulator cancer-associated protein (ANCCA).
Gene name:  ATAD2
Family name: AAA ATPase
Entry whose protein(s) existence is based on evidence at protein level
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1 54 2
GENE REF ISO

Function

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Overview 
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
ATPase activitydefinition[GO:0016887]  
1
  • UniProtKB
Chromatin bindingdefinition[GO:0003682]  
1
  • RefGenome
Histone bindingdefinition[GO:0042393]  
1
  • RefGenome
GO biological process 
Negative regulation of chromatin silencingdefinition[GO:0031936]  
1
  • RefGenome
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • RefGenome
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.1.3: ATP + H(2)O ADP + phosphate.  
1
  • UniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 29028
PRO: PR:Q6PL18