APOA5 - Apolipoprotein A-V - human protein (Function)
 
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APOA5 »  Apolipoprotein A-V  (ApoA-V)
 
Protein also known as:  Regeneration-associated protein 3.
Gene name:  APOA5
Family name: Apolipoprotein A1/A4/E
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 201 1
GENE REF ISO

Function

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Overview 
Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.  
3
  • CuratedUniProtKB
GO molecular function 
Enzyme activator activitydefinition[GO:0008047]  
1
  • IDABHF-UCL
Enzyme bindingdefinition[GO:0019899]  
1
  • IDABHF-UCL
Contributes to heparin bindingdefinition[GO:0008201]  
2
  • IDABHF-UCL
Lipase activator activitydefinition[GO:0060229]  
1
  • IMPBHF-UCL
Lipase bindingdefinition[GO:0035473]  
1
  • IPIBHF-UCL
Lipid bindingdefinition[GO:0008289]  
1
  • IDAUniProtKB
Lipoprotein lipase activator activitydefinition[GO:0060230]  
1
  • IDABHF-UCL
Lipoprotein particle receptor bindingdefinition[GO:0070325]  
1
  • IPIBHF-UCL
Low-density lipoprotein particle receptor bindingdefinition[GO:0050750]  
1
  • IPIBHF-UCL
Phosphatidylcholine bindingdefinition[GO:0031210]  
1
  • IDABHF-UCL
Phospholipid bindingdefinition[GO:0005543]  
1
  • IDABHF-UCL
GO biological process 
Acylglycerol homeostasisdefinition[GO:0055090]  
2
  • IMPBHF-UCL
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • IDABHF-UCL
Lipid transportdefinition[GO:0006869]  
1
  • IDABHF-UCL
Lipoprotein metabolic processdefinition[GO:0042157] silver  
  • IEAInterPro 2 GO
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Positive regulation of fatty acid biosynthetic processdefinition[GO:0045723]  
1
  • IDABHF-UCL
Positive regulation of lipid catabolic processdefinition[GO:0050996]  
1
  • IDABHF-UCL
Positive regulation of lipoprotein lipase activitydefinition[GO:0051006]  
3
  • IDABHF-UCL
Positive regulation of receptor-mediated endocytosisdefinition[GO:0048260]  
1
  • TASBHF-UCL
Positive regulation of triglyceride catabolic processdefinition[GO:0010898]  
1
  • IDABHF-UCL
Positive regulation of very-low-density lipoprotein particle remodelingdefinition[GO:0010902]  
1
  • IDABHF-UCL
Response to hormonedefinition[GO:0009725] silver  
  • IEAOrtholog Compara
Tissue regenerationdefinition[GO:0042246]  
1
  • IEPUniProtKB
Triglyceride catabolic processdefinition[GO:0019433]  
1
  • IMPBHF-UCL
Triglyceride homeostasisdefinition[GO:0070328]  
2
  • IDABHF-UCL
Triglyceride metabolic processdefinition[GO:0006641]  
4
  • IMPHGNC
  • IDABHF-UCL
Triglyceride-rich lipoprotein particle remodelingdefinition[GO:0034370] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
PPAR signaling pathway  hsa03320+116519  
According to Reactome, this protein belongs to the following pathways:
Chylomicron-mediated lipid transport  REACT_6841  
PPARA activates gene expression  REACT_116145  
Note 
Induced in early phase of liver regeneration.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: APOA5
GenomeRNAi: 116519
PRO: PR:Q6Q788