VHLL - Von Hippel-Lindau-like protein - human protein (Function)
 
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VHLL »  Von Hippel-Lindau-like protein  (VLP)
 
Gene name:  VHLL
Family name: VHL
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Functions as a dominant-negative VHL to serve as a protector of HIFalpha.  
2
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Not  Ubiquitin protein ligase activitydefinition[GO:0061630]  
1
  • RefGenome
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
1
  • Ortholog Compara
Blood vessel endothelial cell migrationdefinition[GO:0043534] silver  
1
  • Ortholog Compara
Extracellular matrix organizationdefinition[GO:0030198] silver  
1
  • Ortholog Compara
Negative regulation of endothelial cell differentiationdefinition[GO:0045602] silver  
1
  • Ortholog Compara
Negative regulation of hypoxia-inducible factor-1alpha signaling pathwaydefinition[GO:1902072] silver  
1
  • Ortholog Compara
Negative regulation of thymocyte apoptotic processdefinition[GO:0070244] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Neuron differentiationdefinition[GO:0030182] silver  
1
  • Ortholog Compara
NLS-bearing protein import into nucleusdefinition[GO:0006607] silver  
1
  • Ortholog Compara
Pancreatic A cell differentiationdefinition[GO:0003310] silver  
1
  • Ortholog Compara
Proteasomal protein catabolic processdefinition[GO:0010498] silver  
1
  • Ortholog Compara
Protein heterooligomerizationdefinition[GO:0051291] silver  
1
  • Ortholog Compara
Protein ubiquitinationdefinition[GO:0016567]  
1
  • RefGenome
Regulation of apoptotic signaling pathwaydefinition[GO:2001233] silver  
1
  • Ortholog Compara
Regulation of catecholamine metabolic processdefinition[GO:0042069] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Type B pancreatic cell differentiationdefinition[GO:0003309] silver  
1
  • Ortholog Compara
Note 
Has little or no E3 ubiquitin ligase activity as it lacks the alpha domain required for nucleating the multiprotein E3 ubiquitin ligase complex.  
1
  • UniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 391104
PRO: PR:Q6RSH7