AGTRAP - Type-1 angiotensin II receptor-associated protein - human protein (Function)
 
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AGTRAP »  Type-1 angiotensin II receptor-associated protein
 
Protein also known as:  AT1 receptor-associated protein.
Gene name:  AGTRAP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.  
1
  • CuratedUniProtKB
GO molecular function 
Angiotensin type II receptor activitydefinition[GO:0004945] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Regulation of blood pressuredefinition[GO:0008217] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AGTRAP
GenomeRNAi: 57085
PRO: PR:Q6RW13