FIP1L1 - Pre-mRNA 3'-end-processing factor FIP1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
FIP1L1 »  Pre-mRNA 3'-end-processing factor FIP1
 
Protein also known as:  Rearranged in hypereosinophilia.
Gene name:  FIP1L1
Family name: FIP1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 54 4
GENE REF ISO

Function

 show evidences
Overview 
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.  
1
  • CuratedUniProtKB
GO molecular function 
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
GO biological process 
mRNA processingdefinition[GO:0006397]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
mRNA surveillance pathway  hsa03015+81608  
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FIP1L1
GenomeRNAi: 81608
PRO: PR:Q6UN15