NPNT - Nephronectin - human protein (Function)
 
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Protein
Gene
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NPNT »  Nephronectin
 
Gene name:  NPNT
Family name: Nephronectin
Entry whose protein(s) existence is based on evidence at protein level
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1 22 6
GENE REF ISO

Function

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Overview 
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Integrin bindingdefinition[GO:0005178]  
2
  • ISSBHF-UCL
GO biological process 
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658]  
1
  • ISSBHF-UCL
Cell-cell adhesion mediated by integrindefinition[GO:0033631]  
1
  • ISSBHF-UCL
Cell-matrix adhesiondefinition[GO:0007160]  
1
  • ISSBHF-UCL
Cellular response to tumor necrosis factordefinition[GO:0071356]  
1
  • ISSBHF-UCL
Establishment of protein localizationdefinition[GO:0045184] silver  
  • IEAOrtholog Compara
Extracellular matrix organizationdefinition[GO:0030198]  
1
  • ISSBHF-UCL
Pilomotor reflexdefinition[GO:0097195] silver  
  • IEAOrtholog Compara
Positive regulation of alkaline phosphatase activitydefinition[GO:0010694] silver  
  • IEAOrtholog Compara
Positive regulation of cell-substrate adhesiondefinition[GO:0010811]  
1
  • ISSBHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • ISSBHF-UCL
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • ISSBHF-UCL
Positive regulation of smooth muscle contractiondefinition[GO:0045987] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiationdefinition[GO:2000721] silver  
  • IEAOrtholog Compara
Positive regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030511] silver  
  • IEAOrtholog Compara
Ureteric bud developmentdefinition[GO:0001657]  
1
  • ISSBHF-UCL
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 255743
PRO: PR:Q6UXI9