CASP12 - Inactive caspase-12 - human protein (Function)
 
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CASP12 »  Inactive caspase-12
 
Gene name:  CASP12
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at transcript level
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1 18 3
GENE REF ISO

Function

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Overview 
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.  
2
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197] silver  
  • IBARefGenome
GO biological process 
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968] silver  
  • IEAOrtholog Compara
Not  Execution phase of apoptosisdefinition[GO:0097194] silver  
  • IBARefGenome
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059] silver  
  • IBARefGenome
Proteolysisdefinition[GO:0006508] silver  
  • IEAInterPro 2 GO
Regulation of apoptotic processdefinition[GO:0042981] silver  
  • IEAInterPro 2 GO
Not  Regulation of inflammatory responsedefinition[GO:0050727] silver  
  • IBARefGenome
Enzymatic activity 
 
More information is available from:
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links