APOOL - MICOS complex subunit MIC27 - human protein (Function)
 
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APOOL »  MICOS complex subunit MIC27
 
Protein also known as:  Apolipoprotein O-like.
Gene name:  APOOL
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol.  
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  • UniProtKB
Note 
Overexpression of APOOL results in mitochondrial fragmentation, reduced oxygen consumption, and altered cristae morphology. Down-regulation impairs mitochondrial function and also alters cristae morphology (PubMed23704930).  
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  • UniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 139322
PRO: PR:Q6UXV4