RSPO2 - R-spondin-2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
RSPO2 »  R-spondin-2
 
Protein also known as:  Roof plate-specific spondin-2.
Gene name:  RSPO2
Family name: R-spondin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 20 3
GENE REF ISO

Function

 show evidences
Overview 
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.  
3
  • CuratedUniProtKB
GO molecular function 
Heparin bindingdefinition[GO:0008201] silver  
  • IEAOrtholog Compara
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
GO biological process 
Bone mineralizationdefinition[GO:0030282] silver  
  • IEAOrtholog Compara
Embryonic forelimb morphogenesisdefinition[GO:0035115] silver  
  • IEAOrtholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
  • IEAOrtholog Compara
Epithelial tube branching involved in lung morphogenesisdefinition[GO:0060441] silver  
  • IEAOrtholog Compara
Lung growthdefinition[GO:0060437] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649] silver  
  • IEAOrtholog Compara
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263] silver  
  • IEAOrtholog Compara
Trachea cartilage morphogenesisdefinition[GO:0060535] silver  
  • IEAOrtholog Compara
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Note 
Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis (PubMed16357527).  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Wnt signaling pathway  definition   [KW-0879]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RSPO2
GenomeRNAi: 340419
PRO: PR:Q6UXX9