RSPO2 - R-spondin-2 - human protein (Function)
 
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Protein
Gene
References

 
RSPO2 »  R-spondin-2
 
Protein also known as:  Roof plate-specific spondin-2.
Gene name:  RSPO2
Family name: R-spondin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.  
4
  • UniProtKB
GO molecular function 
G-protein coupled receptor bindingdefinition[GO:0001664]  
1
  • RefGenome
Heparin bindingdefinition[GO:0008201] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
GO biological process 
Bone mineralizationdefinition[GO:0030282] silver  
1
  • Ortholog Compara
Embryonic forelimb morphogenesisdefinition[GO:0035115] silver  
1
  • Ortholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
1
  • Ortholog Compara
Epithelial tube branching involved in lung morphogenesisdefinition[GO:0060441] silver  
1
  • Ortholog Compara
Lung growthdefinition[GO:0060437] silver  
1
  • Ortholog Compara
Osteoblast differentiationdefinition[GO:0001649] silver  
1
  • Ortholog Compara
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • RefGenome
Trachea cartilage morphogenesisdefinition[GO:0060535] silver  
1
  • Ortholog Compara
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
regulation of FZD by ubiquitination  REACT_264580  
Note 
Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis (PubMed16357527).  
2
  • UniProtKB
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Wnt signaling pathway  definition   [KW-0879]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RSPO2
GenomeRNAi: 340419
PRO: PR:Q6UXX9