DPP8 - Dipeptidyl peptidase 8 - human protein (Function)
 
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DPP8 »  Dipeptidyl peptidase 8   [ EC 3.4.14.5 ]  (DP8)
 
Protein also known as:  Dipeptidyl peptidase IV-related protein 1 (DPRP-1).
Gene name:  DPP8
Family name: Peptidase S9B » DPPIV
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function.  
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  • CuratedUniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177]  
  • IEAUniProtKB KW
Dipeptidyl-peptidase activitydefinition[GO:0008239]  
1
  • NASUniProtKB
Serine-type peptidase activitydefinition[GO:0008236]  
  • IEAUniProtKB KW
GO biological process 
Immune responsedefinition[GO:0006955]  
1
  • TASUniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.14.5: Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.  
3
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by zinc. Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate. Specifically inhibited by isoindoline derivatives.  
3
  • CuratedUniProtKB
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 1420 uM for H-Ala-Ala-pNa
KM 310 uM for H-Arg-Pro-pNa
KM 2050 uM for H-Asp-Pro-pNa
KM 120 uM for H-Ala-Pro-pNa
KM 130 uM for Ala-Pro-AFC
KM 208 uM for Ala-Pro-AMC
KM 480 uM for H-Gly-Pro-pNa
Dependence
pH Optimum pH is 7.4-8.5. Little activity below pH 6.5.

Keywords

Molecular function 
Aminopeptidase  definition   [KW-0031]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q6V1X1
Other
GeneWiki: DPP8
GenomeRNAi: 54878
PRO: PR:Q6V1X1
Chemistry
GuidetoPHARMACOLOGY: 2356