BCOR - BCL-6 corepressor - human protein (Function)
 
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BCOR »  BCL-6 corepressor  (BCoR)
 
Gene name:  BCOR
Family name: BCOR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).  
5
  • CuratedUniProtKB
GO molecular function 
Heat shock protein bindingdefinition[GO:0031072]  
1
  • IDAUniProtKB
Histone deacetylase bindingdefinition[GO:0042826]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Transcription corepressor activitydefinition[GO:0003714]  
2
  • IMPUniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIUniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IMPUniProtKB
Contributes to ubiquitin-protein ligase activitydefinition[GO:0004842]  
1
  • IDAUniProtKB
GO biological process 
Heart developmentdefinition[GO:0007507]  
1
  • IMPUniProtKB
Histone H2A monoubiquitinationdefinition[GO:0035518]  
1
  • IDAUniProtKB
Negative regulation of bone mineralizationdefinition[GO:0030502]  
1
  • IMPUniProtKB
Negative regulation of histone H3-K36 methylationdefinition[GO:0000415]  
1
  • IMPUniProtKB
Negative regulation of histone H3-K4 methylationdefinition[GO:0051572]  
1
  • IMPUniProtKB
Negative regulation of tooth mineralizationdefinition[GO:0070171]  
1
  • IMPUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IMPUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
2
  • IMPUniProtKB
Odontogenesisdefinition[GO:0042476]  
1
  • IMPUniProtKB
Palate developmentdefinition[GO:0060021]  
1
  • IMPUniProtKB
Specification of axis polaritydefinition[GO:0065001]  
1
  • IMPUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BCOR
GenomeRNAi: 54880
PRO: PR:Q6W2J9