NPSR1 - Neuropeptide S receptor - human protein (Function)
 
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Protein
Gene
References

 
NPSR1 »  Neuropeptide S receptor
 
Gene name:  NPSR1
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases.  
2
  • CuratedUniProtKB
GO molecular function 
Neuropeptide receptor activitydefinition[GO:0008188] silver  
  • IEAInterPro 2 GO
Vasopressin receptor activitydefinition[GO:0005000] silver  
  • IEAInterPro 2 GO
GO biological process 
Neuropeptide signaling pathwaydefinition[GO:0007218]  
  • IEAInterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
G alpha (s) signalling events  REACT_19327  
Peptide ligand-binding receptors  REACT_14819  
Note 
Only isoforms with 7 transmembrane topology (isoform 1, isoform 3 and isoform 4) are transported into the plasma membrane in transfected cells, while the truncated ones retain intracellular compartments.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Neuropeptide_S_receptor
GenomeRNAi: 387129
PRO: PR:Q6W5P4
Chemistry
GuidetoPHARMACOLOGY: 302