CCBL2 - Kynurenine--oxoglutarate transaminase 3 - human protein (Function)
 
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CCBL2 »  Kynurenine--oxoglutarate transaminase 3   [ EC 2.6.1.7 ]
 
Protein also known as:  Kynurenine--oxoglutarate transaminase III.
Gene name:  CCBL2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 21 3
GENE REF ISO

Function

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Overview 
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Cysteine-S-conjugate beta-lyase activitydefinition[GO:0047804]  
  • IEAEC 2 GO
Kynurenine-glyoxylate transaminase activitydefinition[GO:0047315]  
  • ISSOrtholog Curator
Kynurenine-oxoglutarate transaminase activitydefinition[GO:0016212]  
  • ISSOrtholog Curator
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Pyridoxal phosphate bindingdefinition[GO:0030170] silver  
  • IEAInterPro 2 GO
GO biological process 
2-oxoglutarate metabolic processdefinition[GO:0006103] silver  
  • IEAOrtholog Compara
Biosynthetic processdefinition[GO:0009058] silver  
  • IEAInterPro 2 GO
Cellular amino acid metabolic processdefinition[GO:0006520]  
  • ISSOrtholog Curator
Kynurenine metabolic processdefinition[GO:0070189]  
  • ISSOrtholog Curator
L-kynurenine metabolic processdefinition[GO:0097052]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.6.1.7: L-kynurenine + 2-oxoglutarate 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.  
  • CuratedUniProtKB
EC 4.4.1.13: RS-CH(2)-CH(NH(3)(+))COO(-) + H(2)O RSH + NH(3) + pyruvate.  
  • CuratedUniProtKB
EC 2.6.1.63: L-kynurenine + glyoxylate 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.  
  • CuratedUniProtKB
It requires the following cofactor
Pyridoxal phosphate (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+56267  
Selenocompound metabolism  hsa00450+56267  
Tryptophan metabolism  hsa00380+56267  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
Caution 
The first non-coding exon of CCBL2 is in common with that of RBMXL1.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Aminotransferase  definition   [KW-0032]
Lyase  definition   [KW-0456]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 56267
PRO: PR:Q6YP21