MAP3K15 - Mitogen-activated protein kinase kinase kinase 15 - human protein (Function)
 
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MAP3K15 »  Mitogen-activated protein kinase kinase kinase 15   [ EC 2.7.11.25 ]
 
Protein also known as:  Apoptosis signal-regulating kinase 3.
Gene name:  MAP3K15
Entry whose protein(s) existence is based on evidence at protein level
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1 17 3
GENE REF ISO

Function

 show evidences
Overview 
May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
MAP kinase kinase kinase activitydefinition[GO:0004709]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Activation of MAPKK activitydefinition[GO:0000186]  
  • IEAEC 2 GO
  • IBARefGenome
MAPK cascadedefinition[GO:0000165]  
  • IBARefGenome
  • IEAEC 2 GO
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.25: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-812, inhibited by phosphorylation at Ser-924 and Ser-994 (By similarity).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 389840
PRO: PR:Q6ZN16
Chemistry
GuidetoPHARMACOLOGY: 2075