AEBP2 - Zinc finger protein AEBP2 - human protein (Function)
 
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Protein
Gene
References

 
AEBP2 »  Zinc finger protein AEBP2
 
Protein also known as:  Adipocyte enhancer-binding protein 2 (AE-binding protein 2).
Gene name:  AEBP2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.  
1
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Transcription corepressor activitydefinition[GO:0003714] silver  
  • IEAOrtholog Compara
GO biological process 
Chromatin modificationdefinition[GO:0016568]  
  • IEAUniProtKB KW
Regulation of transcription, DNA-templateddefinition[GO:0006355] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
PRC2 methylates histones and DNA  REACT_200808  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 121536
PRO: PR:Q6ZN18