AGMO - Alkylglycerol monooxygenase - human protein (Function)
 
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AGMO »  Alkylglycerol monooxygenase   [ EC 1.14.16.5 ]
 
Protein also known as:  Transmembrane protein 195.
Gene name:  AGMO
Family name: Sterol desaturase » UPF0476
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes.  
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  • CuratedUniProtKB
GO molecular function 
Glyceryl-ether monooxygenase activitydefinition[GO:0050479]  
1
  • IDAUniProtKB
Iron ion bindingdefinition[GO:0005506]  
1
  • IMPUniProtKB
GO biological process 
Ether lipid metabolic processdefinition[GO:0046485]  
1
  • IDAUniProtKB
Fatty acid biosynthetic processdefinition[GO:0006633] silver  
  • IEAInterPro 2 GO
Membrane lipid metabolic processdefinition[GO:0006643]  
1
  • IDAUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.16.5: 1-alkyl-sn-glycerol + tetrahydrobiopterin + O(2) 1-O-alkyl-sn-glycerol + dihydrobiopterin + H(2)O.  
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  • CuratedUniProtKB
It requires the following cofactor
Iron (Probable).  
1
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 2.58 uM for tetrahydrobiopterin (in presence of ALDH3A2)
KM 11 uM for 1-O pyrenedecyl glycerol (in presence of ALDH3A2)

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 392636
PRO: PR:Q6ZNB7