PQLC2 - Lysosomal amino acid transporter 1 homolog - human protein (Function)
 
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Protein
Gene
References

 
PQLC2 »  Lysosomal amino acid transporter 1 homolog
 
Protein also known as:  PQ-loop repeat-containing protein 2.
Gene name:  PQLC2
Family name: Laat-1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes.  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the lysosomal cystine transporter (lct) family  2.A.43.2.1  
GO molecular function 
Arginine transmembrane transporter activitydefinition[GO:0015181]  
1
  • UniProtKB
Basic amino acid transmembrane transporter activitydefinition[GO:0015174]  
1
  • Ortholog Curator
L-lysine transmembrane transporter activitydefinition[GO:0015189]  
1
  • UniProtKB
GO biological process 
Amino acid homeostasisdefinition[GO:0080144]  
1
  • UniProtKB
Arginine transmembrane transportdefinition[GO:1903826]  
1
  • GOC
Arginine transportdefinition[GO:0015809]  
1
  • UniProtKB
L-lysine transmembrane transportdefinition[GO:1903401]  
1
  • GOC
Lysine transportdefinition[GO:0015819]  
1
  • UniProtKB
Note 
May play a role in the export from lysosomes of cysteamine-cysteine mixed disulfide (MxD), the product formed upon treatment by cysteamine of patients with cystinosis, a disease characterized by the accumulation of cysteine in the lysosomes.  
2
  • UniProtKB
 

Keywords

Biological process 
Amino-acid transport  definition   [KW-0029]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 54896
PRO: PR:Q6ZP29