SRCAP - Helicase SRCAP - human protein (Function)
 
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Protein
Gene
References

 
SRCAP »  Helicase SRCAP   [ EC 3.6.4.- ]
 
Protein also known as:  Snf2-related CBP activator.
Gene name:  SRCAP
Family name: SNF2/RAD54 helicase » SWR1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.  
6
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Helicase activitydefinition[GO:0004386]  
  • IEAUniProtKB KW
Histone acetyltransferase activitydefinition[GO:0004402]  
1
  • TASPINC
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
GO biological process 
Histone acetylationdefinition[GO:0016573]  
1
  • TASGOC
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
 

Biophysicochemical properties

Kinetic parameters
KM 66 uM for ATP

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Chromatin regulator  definition   [KW-0156]
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SRCAP
GenomeRNAi: 10847
PRO: PR:Q6ZRS2