ARHGEF18 - Rho guanine nucleotide exchange factor 18 - human protein (Function)
 
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References

 
ARHGEF18 »  Rho guanine nucleotide exchange factor 18
 
Protein also known as:  114 kDa Rho-specific guanine nucleotide exchange factor (p114RhoGEF).
Gene name:  ARHGEF18
Entry whose protein(s) existence is based on evidence at protein level
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1 32 2
GENE REF ISO

Function

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Overview 
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production.  
3
  • CuratedUniProtKB
GO molecular function 
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
1
  • IDAMGI
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
  • IEAInterPro 2 GO
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036]  
1
  • IDAMGI
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • IDAGOC
Positive regulation of Rho GTPase activitydefinition[GO:0032321]  
  • IEAInterPro 2 GO
Regulation of cell shapedefinition[GO:0008360]  
1
  • IDAMGI
Small GTPase mediated signal transductiondefinition[GO:0007264]  
1
  • IDAMGI
Pathways 
According to Reactome, this protein belongs to the following pathways:
G alpha (12/13) signalling events  REACT_18407  
NRAGE signals death through JNK  REACT_13638  
Rho GTPase cycle  REACT_11051  
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)  REACT_120726  
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 23370
PRO: PR:Q6ZSZ5