ARHGAP27 - Rho GTPase-activating protein 27 - human protein (Function)
 
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References

 
ARHGAP27 »  Rho GTPase-activating protein 27
 
Protein also known as:  CIN85-associated multi-domain-containing Rho GTPase-activating protein 1.
Gene name:  ARHGAP27
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 12 4
GENE REF ISO

Function

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Overview 
Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Rac GTPase activator activitydefinition[GO:0030675]  
  • ISSOrtholog Curator
SH3 domain bindingdefinition[GO:0017124]  
  • ISSOrtholog Curator
GO biological process 
Positive regulation of Cdc42 GTPase activitydefinition[GO:0043089]  
  • ISSOrtholog Curator
Positive regulation of Rac GTPase activitydefinition[GO:0032855]  
  • ISSOrtholog Curator
Receptor-mediated endocytosisdefinition[GO:0006898]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165] silver  
  • IEAInterPro 2 GO
Caution 
According to HGNC, ARHGAP27 and SH3D20 are 2 separate genes, corresponding to isoform 2 and isoform 4, respectively. However, a rat transcript and paralog proteins with a similar domain structure suggest the existence of a single gene encoding for a protein of 889 residues as displayed here.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 201176
PRO: PR:Q6ZUM4