CYP4V2 - Cytochrome P450 4V2 - human protein (Function)
 
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CYP4V2 »  Cytochrome P450 4V2   [ EC 1.14.13.- ]
 
Gene name:  CYP4V2
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
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1 34 2
GENE REF ISO

Function

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Overview 
Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). May have a role in fatty acid and steroid metabolism in the eye.  
1
  • CuratedUniProtKB
GO molecular function 
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Monooxygenase activitydefinition[GO:0004497]  
  • IEAUniProtKB KW
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygendefinition[GO:0016705] silver  
  • IEAInterPro 2 GO
GO biological process 
Fatty acid omega-oxidationdefinition[GO:0010430]  
1
  • IDAUniProtKB
Response to stimulusdefinition[GO:0050896]  
  • IEAUniProtKB KW
Visual perceptiondefinition[GO:0007601]  
  • IEAUniProtKB KW
Enzymatic activity 
It requires the following cofactor
Heme group (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by N-hydroxy-N'-(4-n-butyl-2-methylphenyl formamidine)(HET0016) with an IC(50) of 38 nM.  
1
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
Vmax is the nearly the same for myristic acid and for lauric acid and reduced about 30% for palmitic acid.
KM 430 uM for palmitic acid
KM 140 uM for lauric acid
KM 65 uM for myristic acid

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Vision  definition   [KW-0844]
Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CYP4V2
GenomeRNAi: 285440
PRO: PR:Q6ZWL3