MBOAT2 - Lysophospholipid acyltransferase 2 - human protein (Function)
 
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Protein
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References

 
MBOAT2 »  Lysophospholipid acyltransferase 2   [ EC 2.3.1.- ]  (LPLAT 2)
 
Protein also known as:  Membrane-bound O-acyltransferase domain-containing protein 2 (O-acyltransferase domain-containing protein 2).
Gene name:  MBOAT2
Entry whose protein(s) existence is based on evidence at protein level
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1 12 1
GENE REF ISO

Function

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Overview 
Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.  
1
  • CuratedUniProtKB
GO molecular function 
1-acylglycerol-3-phosphate O-acyltransferase activitydefinition[GO:0003841]  
  • IEAEC 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
Acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine CoA + 1,2-diacyl-sn-glycero-3-phosphoethanolamine.  
  • CuratedUniProtKB
EC 2.3.1.51: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
Partially inhibited by thimerosal.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycerolipid metabolism  hsa00561+129642  
Glycerophospholipid metabolism  hsa00564+129642  
Metabolic pathways  hsa01100+129642  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Phospholipid biosynthesis  definition   [KW-0594]
Phospholipid metabolism  definition   [KW-1208]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 129642
PRO: PR:Q6ZWT7