GTF2H5 - General transcription factor IIH subunit 5 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
GTF2H5 »  General transcription factor IIH subunit 5
 
Protein also known as:  TFIIH basal transcription factor complex TTD-A subunit.
Gene name:  GTF2H5
Family name: TFB5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 13 1
GENE REF ISO

Function

 show evidences
Overview 
Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.  
2
  • UniProtKB
GO molecular function 
rDNA bindingdefinition[GO:0000182] silver  
1
  • Ortholog Compara
GO biological process 
Cellular response to gamma radiationdefinition[GO:0071480] silver  
1
  • Ortholog Compara
Nucleotide-excision repairdefinition[GO:0006289]  
1
  • MGI
Nucleotide-excision repair, preincision complex assemblydefinition[GO:0006294] silver  
1
  • Ortholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB KW
rRNA processingdefinition[GO:0006364] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal transcription factors  hsa03022+404672  
Nucleotide excision repair  hsa03420+404672  
According to Reactome, this protein belongs to the following pathways:
Dual Incision in GG-NER  R-HSA-5696400  
Dual incision in TC-NER  R-HSA-6782135  
Formation of HIV elongation complex in the absence of HIV Tat  R-HSA-167152  
Formation of HIV-1 elongation complex containing HIV-1 Tat  R-HSA-167200  
Formation of Incision Complex in GG-NER  R-HSA-5696395  
Formation of RNA Pol II elongation complex  R-HSA-112382  
Formation of TC-NER Pre-Incision Complex  R-HSA-6781823  
Formation of the Early Elongation Complex  R-HSA-113418  
Formation of the HIV-1 Early Elongation Complex  R-HSA-167158  
Gap-filling DNA repair synthesis and ligation in TC-NER  R-HSA-6782210  
HIV Transcription Initiation  R-HSA-167161  
mRNA Capping  R-HSA-72086  
NoRC negatively regulates rRNA expression  R-HSA-427413  
RNA Pol II CTD phosphorylation and interaction with CE  R-HSA-167160  
RNA Pol II CTD phosphorylation and interaction with CE  R-HSA-77075  
RNA Polymerase I Chain Elongation  R-HSA-73777  
RNA Polymerase I Promoter Escape  R-HSA-73772  
RNA Polymerase I Transcription Initiation  R-HSA-73762  
RNA Polymerase I Transcription Termination  R-HSA-73863  
RNA Polymerase II HIV Promoter Escape  R-HSA-167162  
RNA Polymerase II Pre-transcription Events  R-HSA-674695  
RNA Polymerase II Promoter Escape  R-HSA-73776  
RNA Polymerase II Transcription Elongation  R-HSA-75955  
RNA Polymerase II Transcription Initiation  R-HSA-75953  
RNA Polymerase II Transcription Initiation And Promoter Clearance  R-HSA-76042  
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening  R-HSA-73779  
Tat-mediated elongation of the HIV-1 transcript  R-HSA-167246  
Transcription of the HIV genome  R-HSA-167172  
Transcription-Coupled Nucleotide Excision Repair (TC-NER)  R-HSA-6781827  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GTF2H5
GenomeRNAi: 404672
PRO: PR:Q6ZYL4