USP49 - Ubiquitin carboxyl-terminal hydrolase 49 - human protein (Function)
 
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References

 
USP49 »  Ubiquitin carboxyl-terminal hydrolase 49   [ EC 3.4.19.12 ]
 
Protein also known as:  Ubiquitin-specific-processing protease 49.
Gene name:  USP49
Family name: Peptidase C19
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.  
2
  • UniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • UniProtKB
Histone bindingdefinition[GO:0042393]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
Ubiquitin thiolesterase activitydefinition[GO:0004221]  
1
  • UniProtKB
Ubiquitin-specific protease activitydefinition[GO:0004843]  
2
  • UniProtKB
  • FlyBase
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Histone H2B conserved C-terminal lysine deubiquitinationdefinition[GO:0035616]  
1
  • UniProtKB
mRNA splicing, via spliceosomedefinition[GO:0000398]  
1
  • UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161]  
1
  • RefGenome
Protein deubiquitinationdefinition[GO:0016579]  
1
  • FlyBase
Regulation of proteasomal protein catabolic processdefinition[GO:0061136]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
3
  • UniProtKB
 
More information is available from:
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 25862
PRO: PR:Q70CQ1