CREB3L2 - Cyclic AMP-responsive element-binding protein 3-like protein 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
CREB3L2 »  Cyclic AMP-responsive element-binding protein 3-like protein 2  (cAMP-responsive element-binding protein 3-like protein 2)
 
Protein also known as:  BBF2 human homolog on chromosome 7. Cleaved into:  Processed cyclic AMP-responsive element-binding protein 3-like protein 2.
Gene name:  CREB3L2
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 47 3
GENE REF ISO

Function

 show evidences
Overview 
Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed17178827).  
3
  • UniProtKB
GO molecular function 
cAMP response element bindingdefinition[GO:0035497]  
1
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
1
  • Ortholog Compara
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • UniProtKB
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingdefinition[GO:0001077] silver  
1
  • Ortholog Compara
GO biological process 
Cartilage developmentdefinition[GO:0051216]  
1
  • Ortholog Curator
Chondrocyte differentiationdefinition[GO:0002062]  
1
  • Ortholog Curator
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968] silver  
1
  • InterPro 2 GO
ER to Golgi vesicle-mediated transportdefinition[GO:0006888] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • UniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+64764  
Dopaminergic synapse  hsa04728+64764  
Huntington's disease  hsa05016+64764  
Melanogenesis  hsa04916+64764  
Prostate cancer  hsa05215+64764  
Vasopressin-regulated water reabsorption  hsa04962+64764  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 64764
PRO: PR:Q70SY1