CREB3L2 - Cyclic AMP-responsive element-binding protein 3-like protein 2 - human protein (Function)
 
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CREB3L2 »  Cyclic AMP-responsive element-binding protein 3-like protein 2  (cAMP-responsive element-binding protein 3-like protein 2)
 
Protein also known as:  BBF2 human homolog on chromosome 7. Cleaved into:  Processed cyclic AMP-responsive element-binding protein 3-like protein 2.
Gene name:  CREB3L2
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity).  
1
  • UniProtKB
GO molecular function 
cAMP response element bindingdefinition[GO:0035497]  
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  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
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  • Ortholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
1
  • Ortholog Compara
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
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  • UniProtKB
GO biological process 
Cartilage developmentdefinition[GO:0051216]  
1
  • Ortholog Curator
Chondrocyte differentiationdefinition[GO:0002062]  
1
  • Ortholog Curator
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968] silver  
1
  • InterPro 2 GO
ER to Golgi vesicle-mediated transportdefinition[GO:0006888] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+64764  
Dopaminergic synapse  hsa04728+64764  
Huntington's disease  hsa05016+64764  
Melanogenesis  hsa04916+64764  
Prostate cancer  hsa05215+64764  
Vasopressin-regulated water reabsorption  hsa04962+64764  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 64764
PRO: PR:Q70SY1