CREB3L2 - Cyclic AMP-responsive element-binding protein 3-like protein 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CREB3L2 »  Cyclic AMP-responsive element-binding protein 3-like protein 2  (cAMP-responsive element-binding protein 3-like protein 2)
 
Protein also known as:  BBF2 human homolog on chromosome 7. Cleaved into:  Processed cyclic AMP-responsive element-binding protein 3-like protein 2.
Gene name:  CREB3L2
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 3
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
cAMP response element bindingdefinition[GO:0035497]  
1
  • IMPUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IMPUniProtKB
GO biological process 
Cartilage developmentdefinition[GO:0051216]  
  • ISSOrtholog Curator
Chondrocyte differentiationdefinition[GO:0002062]  
  • ISSOrtholog Curator
ER to Golgi vesicle-mediated transportdefinition[GO:0006888] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • IEPUniProtKB
Response to unfolded proteindefinition[GO:0006986]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+64764  
Dopaminergic synapse  hsa04728+64764  
Huntington's disease  hsa05016+64764  
Melanogenesis  hsa04916+64764  
Prostate cancer  hsa05215+64764  
Vasopressin-regulated water reabsorption  hsa04962+64764  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 64764
PRO: PR:Q70SY1