TUBA1A - Tubulin alpha-1A chain - human protein (Function)
 
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TUBA1A »  Tubulin alpha-1A chain
 
Protein also known as:  Tubulin alpha-3 chain.
Gene name:  TUBA1A
Family name: Tubulin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.  
1
  • UniProtKB
GO molecular function 
GTP bindingdefinition[GO:0005525]  
1
  • UniProtKB KW
GTPase activitydefinition[GO:0003924] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
Protein domain specific bindingdefinition[GO:0019904] silver  
1
  • Ortholog Compara
Structural constituent of cytoskeletondefinition[GO:0005200] silver  
1
  • InterPro 2 GO
Structural molecule activitydefinition[GO:0005198]  
1
  • BHF-UCL
GO biological process 
Cell divisiondefinition[GO:0051301]  
1
  • BHF-UCL
Cytoskeleton-dependent intracellular transportdefinition[GO:0030705]  
1
  • BHF-UCL
Microtubule-based processdefinition[GO:0007017]  
1
  • BHF-UCL
Protein polymerizationdefinition[GO:0051258] silver  
1
  • InterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+7846  
Pathogenic Escherichia coli infection  hsa05130+7846  
Phagosome  hsa04145+7846  
According to Reactome, this protein belongs to the following pathways:
Anchoring of the basal body to the plasma membrane  R-HSA-5620912  
Assembly of the primary cilium  R-HSA-5617833  
Formation of tubulin folding intermediates by CCT/TriC  R-HSA-389960  
Gap junction assembly  R-HSA-190861  
Hedgehog 'off' state  R-HSA-5610787  
Intraflagellar transport  R-HSA-5620924  
Kinesins  R-HSA-983189  
Loss of Nlp from mitotic centrosomes  R-HSA-380259  
Loss of proteins required for interphase microtubule organization from the centrosome  R-HSA-380284  
MHC class II antigen presentation  R-HSA-2132295  
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane  R-HSA-190840  
Mitotic Prometaphase  R-HSA-68877  
Post-chaperonin tubulin folding pathway  R-HSA-389977  
Prefoldin mediated transfer of substrate to CCT/TriC  R-HSA-389957  
Recruitment of mitotic centrosome proteins and complexes  R-HSA-380270  
Recruitment of NuMA to mitotic centrosomes  R-HSA-380320  
Recycling pathway of L1  R-HSA-437239  
Regulation of PLK1 Activity at G2/M Transition  R-HSA-2565942  
Resolution of Sister Chromatid Cohesion  R-HSA-2500257  
RHO GTPases Activate Formins  R-HSA-5663220  
RHO GTPases activate IQGAPs  R-HSA-5626467  
Separation of Sister Chromatids  R-HSA-2467813  
Translocation of GLUT4 to the plasma membrane  R-HSA-1445148  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TUBA1A
GenomeRNAi: 7846
PRO: PR:Q71U36