TUBA1A - Tubulin alpha-1A chain - human protein (Function)
 
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TUBA1A »  Tubulin alpha-1A chain
 
Protein also known as:  Tubulin alpha-3 chain.
Gene name:  TUBA1A
Family name: Tubulin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.  
1
  • UniProtKB
GO molecular function 
GTP bindingdefinition[GO:0005525]  
1
  • UniProtKB KW
GTPase activitydefinition[GO:0003924] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
Protein domain specific bindingdefinition[GO:0019904] silver  
1
  • Ortholog Compara
Structural constituent of cytoskeletondefinition[GO:0005200] silver  
1
  • InterPro 2 GO
Structural molecule activitydefinition[GO:0005198]  
1
  • BHF-UCL
GO biological process 
Cell divisiondefinition[GO:0051301]  
1
  • BHF-UCL
Cytoskeleton-dependent intracellular transportdefinition[GO:0030705]  
1
  • BHF-UCL
Microtubule-based processdefinition[GO:0007017]  
1
  • BHF-UCL
Protein polymerizationdefinition[GO:0051258] silver  
1
  • InterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+7846  
Pathogenic Escherichia coli infection  hsa05130+7846  
Phagosome  hsa04145+7846  
According to Reactome, this protein belongs to the following pathways:
Anchoring of the basal body to the plasma membrane  REACT_267965  
Assembly of the primary cilium  REACT_268265  
Formation of tubulin folding intermediates by CCT/TriC  REACT_16956  
Gap junction assembly  REACT_9509  
Hedgehog 'off' state  REACT_268323  
Intraflagellar transport  REACT_268024  
Kinesins  REACT_25201  
Loss of Nlp from mitotic centrosomes  REACT_15364  
Loss of proteins required for interphase microtubule organization from the centrosome  REACT_15451  
MHC class II antigen presentation  REACT_121399  
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane  REACT_11039  
Mitotic Prometaphase  REACT_682  
Post-chaperonin tubulin folding pathway  REACT_16967  
Prefoldin mediated transfer of substrate to CCT/TriC  REACT_16936  
Recruitment of mitotic centrosome proteins and complexes  REACT_15296  
Recruitment of NuMA to mitotic centrosomes  REACT_15510  
Recycling pathway of L1  REACT_22365  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
Resolution of Sister Chromatid Cohesion  REACT_150425  
Separation of Sister Chromatids  REACT_150471  
Translocation of GLUT4 to the plasma membrane  REACT_147867  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TUBA1A
GenomeRNAi: 7846
PRO: PR:Q71U36