TUBA1A - Tubulin alpha-1A chain - human protein (Function)
 
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TUBA1A »  Tubulin alpha-1A chain
 
Protein also known as:  Tubulin alpha-3 chain.
Gene name:  TUBA1A
Family name: Tubulin
Entry whose protein(s) existence is based on evidence at protein level
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1 57 2
GENE REF ISO

Function

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Overview 
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.  
  • CuratedUniProtKB
GO molecular function 
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
GTPase activitydefinition[GO:0003924] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Structural constituent of cytoskeletondefinition[GO:0005200] silver  
  • IEAInterPro 2 GO
Structural molecule activitydefinition[GO:0005198]  
1
  • TASBHF-UCL
GO biological process 
Cell divisiondefinition[GO:0051301]  
1
  • TASBHF-UCL
Cytoskeleton-dependent intracellular transportdefinition[GO:0030705]  
1
  • TASBHF-UCL
Microtubule-based processdefinition[GO:0007017]  
1
  • TASBHF-UCL
Protein polymerizationdefinition[GO:0051258] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+7846  
Pathogenic Escherichia coli infection  hsa05130+7846  
Phagosome  hsa04145+7846  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Developmental Biology  REACT_111045  
Hemostasis  REACT_604  
Immune System  REACT_6900  
Membrane Trafficking  REACT_11123  
Metabolism of proteins  REACT_17015  
Mitotic M-M/G1 phases  REACT_21300  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TUBA1A
GenomeRNAi: 7846
PRO: PR:Q71U36