SUPT6H - Transcription elongation factor SPT6 - human protein (Function)
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SUPT6H »  Transcription elongation factor SPT6
Protein also known as:  Histone chaperone suppressor of Ty6.
Gene name:  SUPT6H
Family name: SPT6
Entry whose protein(s) existence is based on evidence at protein level
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Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
Hydrolase activity, acting on ester bondsdefinition[GO:0016788] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
  • IPIUniProtKB
  • IPIIntAct
RNA bindingdefinition[GO:0003723] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
GO biological process 
Chromatin remodelingdefinition[GO:0006338]  
  • NASUniProtKB
mRNA processingdefinition[GO:0006397]  
  • IEAUniProtKB KW
mRNA transportdefinition[GO:0051028]  
  • IEAUniProtKB KW
Negative regulation of histone H3-K27 methylationdefinition[GO:0061086]  
  • IMPUniProtKB
Positive regulation of transcription elongation from RNA polymerase II promoterdefinition[GO:0032968]  
  • IMPUniProtKB
Regulation of isotype switchingdefinition[GO:0045191]  
  • ISSOrtholog Curator
Regulation of mRNA export from nucleusdefinition[GO:0010793]  
  • ISSOrtholog Curator
Regulation of mRNA processingdefinition[GO:0050684]  
  • ISSOrtholog Curator
Regulation of muscle cell differentiationdefinition[GO:0051147]  
  • ISSOrtholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • NASUniProtKB
RNA splicingdefinition[GO:0008380]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW


Biological process 
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Transport  definition   [KW-0813]
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
mRNA transport  definition   [KW-0509]
Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: SUPT6H
GenomeRNAi: 6830