MARK2 - Serine/threonine-protein kinase MARK2 - human protein (Function)
 
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MARK2 »  Serine/threonine-protein kinase MARK2   [ EC 2.7.11.26EC 2.7.11.1 ]
 
Protein also known as:  MAP/microtubule affinity-regulating kinase 2.
Gene name:  MARK2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • IDAUniProtKB
Lipid bindingdefinition[GO:0008289]  
  • IEAUniProtKB KW
Magnesium ion bindingdefinition[GO:0000287]  
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  • IDAUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IPIIntAct
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • IDAUniProtKB
Tau-protein kinase activitydefinition[GO:0050321]  
  • ISSOrtholog Curator
GO biological process 
Establishment of cell polaritydefinition[GO:0030010]  
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  • TASUniProtKB
Establishment or maintenance of epithelial cell apical/basal polaritydefinition[GO:0045197]  
1
  • IDAUniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAUniProtKB
Neuron migrationdefinition[GO:0001764]  
  • ISSOrtholog Curator
Positive regulation of neuron projection developmentdefinition[GO:0010976]  
1
  • IDAUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468]  
2
  • IDAUniProtKB
Regulation of axonogenesisdefinition[GO:0050770]  
1
  • IMPUniProtKB
Regulation of cytoskeleton organizationdefinition[GO:0051493]  
  • ISSOrtholog Curator
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
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  • CuratedUniProtKB
EC 2.7.11.26: ATP + [tau protein] ADP + [tau protein] phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
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  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by PAK7/PAK5; inhibition is independent of the kinase activity of PAK7/PAK5 (By similarity). Activated by phosphorylation on Thr-208. Inhibited by phosphorylation at Ser-212 and Thr-596. Inhibited by hymenialdisine. Specifically inhibited by the H.pylori CagA peptide FPLKRHDKVDDLSK that mimics host substrates and binds to the kinase substrate-binding site.  
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  • CuratedUniProtKB
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MARK2
GenomeRNAi: 2011
PRO: PR:Q7KZI7
Chemistry
GuidetoPHARMACOLOGY: 2098