MARK2 - Serine/threonine-protein kinase MARK2 - human protein (Function)
 
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MARK2 »  Serine/threonine-protein kinase MARK2   [ EC 2.7.11.26EC 2.7.11.1 ]
 
Protein also known as:  MAP/microtubule affinity-regulating kinase 2.
Gene name:  MARK2
Entry whose protein(s) existence is based on evidence at protein level
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1 113 16
GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.  
11
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
Lipid bindingdefinition[GO:0008289]  
1
  • UniProtKB KW
Magnesium ion bindingdefinition[GO:0000287]  
1
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
16
  • IntAct
  • UniProtKB
Protein kinase activator activitydefinition[GO:0030295]  
1
  • ParkinsonsUK-UCL
Protein serine/threonine kinase activitydefinition[GO:0004674]  
6
  • ParkinsonsUK-UCL
  • UniProtKB
Tau-protein kinase activitydefinition[GO:0050321]  
1
  • Ortholog Curator
GO biological process 
Activation of protein kinase activitydefinition[GO:0032147]  
1
  • ParkinsonsUK-UCL
Establishment of cell polaritydefinition[GO:0030010]  
2
  • UniProtKB
Establishment or maintenance of epithelial cell apical/basal polaritydefinition[GO:0045197]  
1
  • UniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • UniProtKB
Mitochondrion degradationdefinition[GO:0000422]  
1
  • ParkinsonsUK-UCL
Mitochondrion localizationdefinition[GO:0051646]  
1
  • ParkinsonsUK-UCL
Neuron migrationdefinition[GO:0001764]  
1
  • Ortholog Curator
Peptidyl-threonine phosphorylationdefinition[GO:0018107]  
1
  • ParkinsonsUK-UCL
Positive regulation of neuron projection developmentdefinition[GO:0010976]  
1
  • UniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • Ortholog Curator
Protein phosphorylationdefinition[GO:0006468]  
2
  • UniProtKB
Regulation of axonogenesisdefinition[GO:0050770]  
1
  • UniProtKB
Regulation of cytoskeleton organizationdefinition[GO:0051493]  
1
  • Ortholog Curator
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
2
  • UniProtKB
EC 2.7.11.26: ATP + [tau protein] ADP + [tau protein] phosphate.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
Inhibited by PAK7/PAK5; inhibition is independent of the kinase activity of PAK7/PAK5 (By similarity). Activated by phosphorylation on Thr-208. Inhibited by phosphorylation at Ser-212 and Thr-596. Inhibited by hymenialdisine. Specifically inhibited by the H.pylori CagA peptide FPLKRHDKVDDLSK that mimics host substrates and binds to the kinase substrate-binding site.  
3
  • UniProtKB
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MARK2
GenomeRNAi: 2011
PRO: PR:Q7KZI7
Chemistry
GuidetoPHARMACOLOGY: 2098