FA2H - Fatty acid 2-hydroxylase - human protein (Function)
 
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FA2H »  Fatty acid 2-hydroxylase   [ EC 1.-.-.- ]
 
Protein also known as:  Fatty acid alpha-hydroxylase.
Gene name:  FA2H
Family name: Sterol desaturase » SCS7
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids.  
2
  • CuratedUniProtKB
GO molecular function 
Fatty acid alpha-hydroxylase activitydefinition[GO:0080132] silver  
  • IEAOrtholog Compara
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Central nervous system myelin maintenancedefinition[GO:0032286] silver  
  • IEAOrtholog Compara
Fatty acid biosynthetic processdefinition[GO:0006633]  
  • IEAUniProtKB KW
Lipid modificationdefinition[GO:0030258] silver  
  • IEAOrtholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Peripheral nervous system myelin maintenancedefinition[GO:0032287] silver  
  • IEAOrtholog Compara
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Regulation of hair cycledefinition[GO:0042634] silver  
  • IEAOrtholog Compara
Sebaceous gland cell differentiationdefinition[GO:0001949] silver  
  • IEAOrtholog Compara
Sphingolipid metabolic processdefinition[GO:0006665] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
It requires the following cofactor
Iron (By similarity).  
  • CuratedUniProtKB
Pathways 
 
More information is available from:
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Fatty acid biosynthesis  definition   [KW-0275]
Fatty acid metabolism  definition   [KW-0276]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Transport  definition   [KW-0813]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FA2H
GenomeRNAi: 79152
PRO: PR:Q7L5A8