HIST3H2A - Histone H2A type 3 - human protein (Function)
 
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Protein
Gene
References

 
HIST3H2A »  Histone H2A type 3
 
Gene name:  HIST3H2A
Family name: Histone H2A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAInterPro 2 GO
GO biological process 
Nucleosome assemblydefinition[GO:0006334] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Systemic lupus erythematosus  hsa05322+92815  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HIST3H2A
GenomeRNAi: 92815
PRO: PR:Q7L7L0