TAOK1 - Serine/threonine-protein kinase TAO1 - human protein (Function)
 
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TAOK1 »  Serine/threonine-protein kinase TAO1   [ EC 2.7.11.1 ]
 
Protein also known as:  Thousand and one amino acid protein kinase 1 (TAOK1).
Gene name:  TAOK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 49 3
GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.  
8
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • NASHGNC
Kinase activitydefinition[GO:0016301]  
1
  • NASHGNC
MAP kinase kinase kinase activitydefinition[GO:0004709] silver  
  • IBARefGenome
Protein kinase activitydefinition[GO:0004672]  
1
  • NASHGNC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • NASHGNC
  • ISSOrtholog Curator
Transferase activitydefinition[GO:0016740]  
1
  • NASHGNC
GO biological process 
Activation of MAPKK activitydefinition[GO:0000186] silver  
  • IBARefGenome
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IDAUniProtKB
DNA repairdefinition[GO:0006281]  
  • IEAUniProtKB KW
Execution phase of apoptosisdefinition[GO:0097194]  
1
  • IDAUniProtKB
G2 DNA damage checkpointdefinition[GO:0031572]  
1
  • IMPUniProtKB
MAPK cascadedefinition[GO:0000165] silver  
  • IBARefGenome
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • IDAUniProtKB
Positive regulation of stress-activated MAPK cascadedefinition[GO:0032874]  
1
  • IMPUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • NASHGNC
Regulation of cytoskeleton organizationdefinition[GO:0051493]  
  • ISSOrtholog Curator
Not  Spindle checkpointdefinition[GO:0031577]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Serine/threonine-protein kinase activity is inhibited by SPRED1.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
MAPK signaling pathway  hsa04010+57551  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Mitotic M-M/G1 phases  REACT_21300  
Caution 
Was initially thought to play a role in the spindle checkpoint (PubMed17417629). However, it was later shown that it is not the case and that phenotypes initially observed are the cause of the siRNA used that has an off-target effect resulting in MAD2L1 inhibition (PubMed19904549 and PubMed20162290).  
3
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TAOK1
GenomeRNAi: 57551
PRO: PR:Q7L7X3
Chemistry
GuidetoPHARMACOLOGY: 2233