CHST3 - Carbohydrate sulfotransferase 3 - human protein (Function)
 
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Protein
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References

 
CHST3 »  Carbohydrate sulfotransferase 3   [ EC 2.8.2.17 ]
 
Protein also known as:  Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0 (GST-0).
Gene name:  CHST3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.  
2
  • CuratedUniProtKB
GO molecular function 
Chondroitin 6-sulfotransferase activitydefinition[GO:0008459]  
1
  • IDAUniProtKB
Proteoglycan sulfotransferase activitydefinition[GO:0050698] silver  
  • IEAOrtholog Compara
Sulfotransferase activitydefinition[GO:0008146]  
1
  • TASPINC
GO biological process 
Chondroitin sulfate biosynthetic processdefinition[GO:0030206]  
1
  • IDAUniProtKB
Sulfur compound metabolic processdefinition[GO:0006790]  
1
  • IDAUniProtKB
T cell homeostasisdefinition[GO:0043029] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.8.2.17: 3'-phosphoadenylyl sulfate + chondroitin adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Glycosaminoglycan biosynthesis - chondroitin sulfate  hsa00532+9469  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 9469
PRO: PR:Q7LGC8