STRADA - STE20-related kinase adapter protein alpha - human protein (Function)
 
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STRADA »  STE20-related kinase adapter protein alpha  (STRAD alpha)
 
Protein also known as:  Serologically defined breast cancer antigen NY-BR-96.
Gene name:  STRADA
Entry whose protein(s) existence is based on evidence at protein level
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1 35 6
GENE REF ISO

Function

 show evidences
Overview 
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Kinase bindingdefinition[GO:0019900]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Protein kinase activator activitydefinition[GO:0030295]  
1
  • IDAUniProtKB
Not  Protein kinase activitydefinition[GO:0004672]  
1
  • IDAUniProtKB
Contributes to protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDABHF-UCL
GO biological process 
Activation of protein kinase activitydefinition[GO:0032147]  
1
  • IDAUniProtKB
Protein export from nucleusdefinition[GO:0006611]  
1
  • IDAUniProtKB
Contradiction  Protein phosphorylationdefinition[GO:0006468]  
2
  • IDAGOC
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
mTOR signaling pathway  hsa04150+92335  
According to Reactome, this protein belongs to the following pathway:
Regulation of AMPK activity via LKB1  REACT_21285  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LYK5
GenomeRNAi: 92335
PRO: PR:Q7RTN6