BHLHA15 - Class A basic helix-loop-helix protein 15 - human protein (Function)
 
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BHLHA15 »  Class A basic helix-loop-helix protein 15  (bHLHa15)
 
Protein also known as:  Muscle, intestine and stomach expression 1 (MIST-1).
Gene name:  BHLHA15
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 15 1
GENE REF ISO

Function

 show evidences
Overview 
Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).  
1
  • UniProtKB
GO molecular function 
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977] silver  
1
  • Ortholog Compara
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001228] silver  
1
  • Ortholog Compara
GO biological process 
Calcium-mediated signalingdefinition[GO:0019722] silver  
1
  • Ortholog Compara
Cell maturationdefinition[GO:0048469] silver  
1
  • Ortholog Compara
Cell-cell signalingdefinition[GO:0007267] silver  
1
  • Ortholog Compara
Cellular response to glucose starvationdefinition[GO:0042149]  
1
  • Ortholog Curator
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968]  
1
  • Ortholog Curator
G-protein coupled receptor signaling pathwaydefinition[GO:0007186] silver  
1
  • Ortholog Compara
Glucose homeostasisdefinition[GO:0042593] silver  
1
  • Ortholog Compara
Golgi organizationdefinition[GO:0007030] silver  
1
  • Ortholog Compara
Intracellular distribution of mitochondriadefinition[GO:0048312] silver  
1
  • Ortholog Compara
Mitochondrial calcium ion transportdefinition[GO:0006851] silver  
1
  • Ortholog Compara
Negative regulation of myotube differentiationdefinition[GO:0010832]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Maturity onset diabetes of the young  hsa04950+168620  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BHLHB8
GenomeRNAi: 168620
PRO: PR:Q7RTS1