PTF1A - Pancreas transcription factor 1 subunit alpha - human protein (Function)
 
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PTF1A »  Pancreas transcription factor 1 subunit alpha
 
Protein also known as:  p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48).
Gene name:  PTF1A
Entry whose protein(s) existence is based on evidence at protein level
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1 17 1
GENE REF ISO

Function

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Overview 
Transcriptional activator. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays an important role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells (By similarity). Plays an important role in cerebellar development.  
1
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • ISSOrtholog Curator
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
GO biological process 
Embryo developmentdefinition[GO:0009790] silver  
  • IEAOrtholog Compara
Exocrine pancreas developmentdefinition[GO:0031017]  
  • ISSOrtholog Curator
Hindbrain developmentdefinition[GO:0030902] silver  
  • IEAOrtholog Compara
Neuron fate commitmentdefinition[GO:0048663] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • ISSOrtholog Curator
Retina morphogenesis in camera-type eyedefinition[GO:0060042] silver  
  • IEAOrtholog Compara
Retinoic acid receptor signaling pathwaydefinition[GO:0048384] silver  
  • IEAOrtholog Compara
Tissue developmentdefinition[GO:0009888]  
1
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
Note 
An excellent marker of acinar cell differentiation in the pancreas.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PTF1A
GenomeRNAi: 256297
PRO: PR:Q7RTS3