PTF1A - Pancreas transcription factor 1 subunit alpha - human protein (Function)
 
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PTF1A »  Pancreas transcription factor 1 subunit alpha
 
Protein also known as:  p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48).
Gene name:  PTF1A
Entry whose protein(s) existence is based on evidence at protein level
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1 17 1
GENE REF ISO

Function

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Overview 
Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.  
2
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • ISSOrtholog Curator
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
GO biological process 
Amacrine cell differentiationdefinition[GO:0035881]  
  • ISSOrtholog Curator
Cerebellum developmentdefinition[GO:0021549]  
1
  • IMPUniProtKB
Embryo developmentdefinition[GO:0009790] silver  
  • IEAOrtholog Compara
Exocrine pancreas developmentdefinition[GO:0031017]  
  • ISSOrtholog Curator
Neuron fate commitmentdefinition[GO:0048663] silver  
  • IEAOrtholog Compara
Pancreas developmentdefinition[GO:0031016]  
1
  • IMPUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Regulation of neural retina developmentdefinition[GO:0061074]  
  • ISSOrtholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • ISSOrtholog Curator
Retina layer formationdefinition[GO:0010842]  
  • ISSOrtholog Curator
Retinoic acid receptor signaling pathwaydefinition[GO:0048384] silver  
  • IEAOrtholog Compara
Tissue developmentdefinition[GO:0009888]  
1
  • IDAUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Regulation of gene expression in early pancreatic precursor cells  REACT_13778  
Note 
An excellent marker of acinar cell differentiation in the pancreas.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PTF1A
GenomeRNAi: 256297
PRO: PR:Q7RTS3