TRPM8 - Transient receptor potential cation channel subfamily M member 8 - human protein (Function)
 
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TRPM8 »  Transient receptor potential cation channel subfamily M member 8
 
Protein also known as:  Long transient receptor potential channel 6 (LTrpC6).
Gene name:  TRPM8
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity.  
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  • CuratedUniProtKB
Isoforms  Iso 2 and Iso 3   Negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.  
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  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the transient receptor potential ca(2+) channel (trp-cc) family  1.A.4.5.7  
GO molecular function 
Calcium channel activitydefinition[GO:0005262] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
Cellular calcium ion homeostasisdefinition[GO:0006874] silver  
  • IEAOrtholog Compara
Protein homotetramerizationdefinition[GO:0051289] silver  
  • IEAOrtholog Compara
Protein homotrimerizationdefinition[GO:0070207] silver  
  • IEAOrtholog Compara
Response to colddefinition[GO:0009409] silver  
  • IEAOrtholog Compara
Thermoceptiondefinition[GO:0050955] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
Note 
The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein.  
  • CuratedUniProtKB
Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest that it may be suitable for the design of peptide vaccination strategies for prostate cancers.  
  • CuratedUniProtKB
Caution 
The 192-residue sequence submitted as AAS45276 has been confirmed by the authors of PubMed22128173 to be incorrect as translation starts from a downstream methionine.  
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  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sensory transduction  definition   [KW-0716]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPM8
GenomeRNAi: 79054
PRO: PR:Q7Z2W7
Chemistry
GuidetoPHARMACOLOGY: 500