NRK - Nik-related protein kinase - human protein (Function)
 
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NRK »  Nik-related protein kinase   [ EC 2.7.11.1 ]
 
Gene name:  NRK
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Not  MAP kinase kinase kinase kinase activitydefinition[GO:0008349]  
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  • RefGenome
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
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  • RefGenome
Activation of JNKK activitydefinition[GO:0007256] silver  
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  • Ortholog Compara
Activation of protein kinase activitydefinition[GO:0032147]  
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  • RefGenome
MAPK cascadedefinition[GO:0000165]  
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  • RefGenome
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
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  • Ortholog Compara
Neuron projection morphogenesisdefinition[GO:0048812]  
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  • RefGenome
Parturitiondefinition[GO:0007567] silver  
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  • Ortholog Compara
Regulation of apoptotic processdefinition[GO:0042981]  
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  • RefGenome
Regulation of mitotic cell cycledefinition[GO:0007346]  
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  • RefGenome
Regulation of spongiotrophoblast cell proliferationdefinition[GO:0060721] silver  
1
  • Ortholog Compara
Stress-activated protein kinase signaling cascadedefinition[GO:0031098]  
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  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
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  • UniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NRK_(gene)
GenomeRNAi: 203447
PRO: PR:Q7Z2Y5