KANSL1 - KAT8 regulatory NSL complex subunit 1 - human protein (Function)
 
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Protein
Gene
References

 
KANSL1 »  KAT8 regulatory NSL complex subunit 1
 
Protein also known as:  MLL1/MLL complex subunit KANSL1.
Gene name:  KANSL1
Entry whose protein(s) existence is based on evidence at protein level
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1 43 2
GENE REF ISO

Function

 show evidences
Overview 
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.  
2
  • CuratedUniProtKB
GO molecular function 
Contributes to histone acetyltransferase activity (H4-K16 specific)definition[GO:0046972]  
1
  • IDAUniProtKB
Contributes to histone acetyltransferase activity (H4-K5 specific)definition[GO:0043995]  
1
  • IDAUniProtKB
Contributes to histone acetyltransferase activity (H4-K8 specific)definition[GO:0043996]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Histone H4-K16 acetylationdefinition[GO:0043984]  
1
  • IDAUniProtKB
Histone H4-K5 acetylationdefinition[GO:0043981]  
1
  • IDAUniProtKB
Histone H4-K8 acetylationdefinition[GO:0043982]  
1
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
HATs acetylate histones  REACT_172610  
 

Keywords

Molecular function 
Chromatin regulator  definition   [KW-0156]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KIAA1267
GenomeRNAi: 284058
PRO: PR:Q7Z3B3