SPRED1 - Sprouty-related, EVH1 domain-containing protein 1 - human protein (Function)
 
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Protein
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SPRED1 »  Sprouty-related, EVH1 domain-containing protein 1
 
Gene name:  SPRED1
Entry whose protein(s) existence is based on evidence at protein level
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1 43 1
GENE REF ISO

Function

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Overview 
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Phosphatase bindingdefinition[GO:0019902]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
Protein serine/threonine kinase inhibitor activitydefinition[GO:0030291]  
1
  • ISSBHF-UCL
Stem cell factor receptor bindingdefinition[GO:0005173]  
  • ISSOrtholog Curator
GO biological process 
Inactivation of MAPK activitydefinition[GO:0000188]  
  • ISSOrtholog Curator
Multicellular organismal developmentdefinition[GO:0007275] silver  
  • IEAInterPro 2 GO
Negative regulation of peptidyl-threonine phosphorylationdefinition[GO:0010801]  
1
  • IMPBHF-UCL
Negative regulation of phosphatase activitydefinition[GO:0010923]  
1
  • IDAUniProtKB
Positive regulation of DNA damage response, signal transduction by p53 class mediatordefinition[GO:0043517]  
1
  • ISSBHF-UCL
Regulation of protein deacetylationdefinition[GO:0090311]  
1
  • ISSBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Jak-STAT signaling pathway  hsa04630+161742  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SPRED1
GenomeRNAi: 161742
PRO: PR:Q7Z699