RBBP6 - E3 ubiquitin-protein ligase RBBP6 - human protein (Function)
 
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Protein
Gene
References

 
RBBP6 »  E3 ubiquitin-protein ligase RBBP6   [ EC 6.3.2.- ]
 
Protein also known as:  p53-associated cellular protein of testis.
Gene name:  RBBP6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 92 4
GENE REF ISO

Function

 show evidences
Overview 
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed24726359).  
4
  • UniProtKB
GO molecular function 
Ligase activitydefinition[GO:0016874]  
1
  • UniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • UniProtKB
  • IntAct
Ubiquitin protein ligase activitydefinition[GO:0061630]  
1
  • UniProtKB
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
1
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • UniProtKB
DNA replicationdefinition[GO:0006260]  
1
  • UniProtKB KW
Embryonic organ developmentdefinition[GO:0048568] silver  
1
  • Ortholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
1
  • Ortholog Compara
Protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:0042787]  
2
  • UniProtKB
Regulation of DNA replicationdefinition[GO:0006275]  
1
  • UniProtKB
Somite developmentdefinition[GO:0061053] silver  
1
  • Ortholog Compara
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
1
  • UniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA replication  definition   [KW-0235]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RBBP6
GenomeRNAi: 5930
PRO: PR:Q7Z6E9