RBBP6 - E3 ubiquitin-protein ligase RBBP6 - human protein (Function)
 
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Protein
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References

 
RBBP6 »  E3 ubiquitin-protein ligase RBBP6   [ EC 6.3.2.- ]
 
Protein also known as:  p53-associated cellular protein of testis.
Gene name:  RBBP6
Entry whose protein(s) existence is based on evidence at protein level
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1 53 4
GENE REF ISO

Function

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Overview 
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.  
  • CuratedUniProtKB
GO molecular function 
Nucleic acid bindingdefinition[GO:0003676] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
Ubiquitin-protein ligase activitydefinition[GO:0004842]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Embryonic organ developmentdefinition[GO:0048568] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:0042787]  
1
  • IDAUniProtKB
Somite developmentdefinition[GO:0061053] silver  
  • IEAOrtholog Compara
Pathways 
This protein is involved in the following pathway
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RBBP6
GenomeRNAi: 5930
PRO: PR:Q7Z6E9