TSEN54 - tRNA-splicing endonuclease subunit Sen54 - human protein (Function)
 
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TSEN54 »  tRNA-splicing endonuclease subunit Sen54
 
Protein also known as:  tRNA-intron endonuclease Sen54.
Gene name:  TSEN54
Family name: SEN54
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.  
1
  • CuratedUniProtKB
GO biological process 
mRNA processingdefinition[GO:0006397]  
  • IEAUniProtKB KW
tRNA splicing, via endonucleolytic cleavage and ligationdefinition[GO:0006388]  
1
  • IDAUniProtKB
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
tRNA processing  definition   [KW-0819]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 283989
PRO: PR:Q7Z6J9