HUWE1 - E3 ubiquitin-protein ligase HUWE1 - human protein (Function)
 
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HUWE1 »  E3 ubiquitin-protein ligase HUWE1   [ EC 6.3.2.- ]
 
Protein also known as:  Homologous to E6AP carboxyl terminus homologous protein 9 (HectH9).
Gene name:  HUWE1
Family name: UPL » TOM1/PTR1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 118 3
GENE REF ISO

Function

 show evidences
Overview 
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4.  
9
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • Ortholog Curator
Ligase activitydefinition[GO:0016874]  
1
  • UniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
2
  • UniProtKB
GO biological process 
Base-excision repairdefinition[GO:0006284]  
1
  • UniProtKB
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB KW
Histone ubiquitinationdefinition[GO:0016574]  
1
  • UniProtKB
Positive regulation of protein targeting to mitochondriondefinition[GO:1903955]  
1
  • ParkinsonsUK-UCL
Protein monoubiquitinationdefinition[GO:0006513]  
1
  • UniProtKB
Protein polyubiquitinationdefinition[GO:0000209]  
1
  • UniProtKB
Protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:0042787]  
1
  • RefGenome
Enzymatic activity 
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
1
  • UniProtKB
According to Reactome, this protein belongs to the following pathway:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Differentiation  definition   [KW-0221]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HUWE1
GenomeRNAi: 10075
PRO: PR:Q7Z6Z7