CNTRL - Centriolin - human protein (Function)
 
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Protein
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CNTRL »  Centriolin
 
Protein also known as:  Centrosomal protein of 110 kDa (Cep110).
Gene name:  CNTRL
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Cell divisiondefinition[GO:0051301]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Loss of Nlp from mitotic centrosomes  REACT_15364  
Loss of proteins required for interphase microtubule organization from the centrosome  REACT_15451  
Recruitment of mitotic centrosome proteins and complexes  REACT_15296  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
Signaling by FGFR1 fusion mutants  REACT_121141  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CNTRL
GenomeRNAi: 11064
PRO: PR:Q7Z7A1