VTCN1 - V-set domain-containing T-cell activation inhibitor 1 - human protein (Function)
 
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VTCN1 »  V-set domain-containing T-cell activation inhibitor 1
 
Protein also known as:  Immune costimulatory protein B7-H4.
Gene name:  VTCN1
Family name: Immunoglobulin » BTN/MOG
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.  
4
  • CuratedUniProtKB
GO molecular function 
Receptor bindingdefinition[GO:0005102] silver  
  • IEAOrtholog Compara
GO biological process 
Immune system processdefinition[GO:0002376]  
  • IEAUniProtKB KW
Interferon-gamma secretiondefinition[GO:0072643] silver  
  • IEAOrtholog Compara
Interleukin-4 secretiondefinition[GO:0072602] silver  
  • IEAOrtholog Compara
Negative regulation of T cell activationdefinition[GO:0050868] silver  
  • IEAOrtholog Compara
Response to protozoandefinition[GO:0001562] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
Note 
May serve as a predictive marker for renal cell carcinoma.  
1
  • CuratedUniProtKB
Caution 
The mouse ortholog has been shown (PubMed12818166) to be a GPI-anchored protein but the Gly residue which is predicted to be the modified site in mouse and rat is not conserved in human.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Immunity  definition   [KW-0391]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: VTCN1
GenomeRNAi: 79679
PRO: PR:Q7Z7D3