GALNT10 - Polypeptide N-acetylgalactosaminyltransferase 10 - human protein (Function)
 
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GALNT10 »  Polypeptide N-acetylgalactosaminyltransferase 10   [ EC 2.4.1.41 ]
 
Protein also known as:  UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10.
Gene name:  GALNT10
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.  
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  • UniProtKB
GO molecular function 
Carbohydrate bindingdefinition[GO:0030246]  
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  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
Polypeptide N-acetylgalactosaminyltransferase activitydefinition[GO:0004653]  
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  • GO_central
GO biological process 
O-glycan processingdefinition[GO:0016266]  
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  • GO_central
Protein O-linked glycosylationdefinition[GO:0006493]  
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  • GO_central
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.41: UDP-N-acetyl-alpha-D-galactosamine + polypeptide UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.  
2
  • UniProtKB
It requires the following cofactor
 Mn(2+)  
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  • UniProtKB
According to CAZy, this protein is belongs to the following pathways:
Carbohydrate-Binding Module Family 13  CBM13  
Glycosyltransferase Family 27  GT27  
Pathways 
This protein is involved in the following pathway
Protein modification; protein glycosylation  
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  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+55568  
Mucin type O-Glycan biosynthesis  hsa00512+55568  
According to Reactome, this protein belongs to the following pathway:
O-linked glycosylation of mucins  REACT_115606  
Caution 
According to experiments made in rat, this enzyme is unable to transfer GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties, thereby acting as a glycopeptide transferase.  
1
  • UniProtKB
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 55568
PRO: PR:Q86SR1