GALNT10 - Polypeptide N-acetylgalactosaminyltransferase 10 - human protein (Function)
 
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GALNT10 »  Polypeptide N-acetylgalactosaminyltransferase 10   [ EC 2.4.1.41 ]
 
Protein also known as:  UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10.
Gene name:  GALNT10
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 23 4
GENE REF ISO

Function

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Overview 
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.  
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Polypeptide N-acetylgalactosaminyltransferase activitydefinition[GO:0004653]  
  • IEAEC 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.41: UDP-N-acetyl-alpha-D-galactosamine + polypeptide UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.  
1
  • CuratedUniProtKB
It requires the following cofactor
Manganese (By similarity).  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathways:
Carbohydrate-Binding Module Family 13  CBM13  
Glycosyltransferase Family 27  GT27  
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+55568  
Mucin type O-Glycan biosynthesis  hsa00512+55568  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
Caution 
According to experiments made in rat, this enzyme is unable to transfer GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties, thereby acting as a glycopeptide transferase.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 55568
PRO: PR:Q86SR1