SYVN1 - E3 ubiquitin-protein ligase synoviolin - human protein (Function)
 
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SYVN1 »  E3 ubiquitin-protein ligase synoviolin   [ EC 6.3.2.- ]
 
Protein also known as:  Synovial apoptosis inhibitor 1.
Gene name:  SYVN1
Family name: HRD1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 92 3
GENE REF ISO

Function

 show evidences
Overview 
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.  
11
  • UniProtKB
GO molecular function 
ATPase bindingdefinition[GO:0051117]  
2
  • ParkinsonsUK-UCL
Chaperone bindingdefinition[GO:0051087]  
1
  • ParkinsonsUK-UCL
Ligase activitydefinition[GO:0016874]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
7
  • ParkinsonsUK-UCL
  • UniProtKB
  • IntAct
Ubiquitin protein ligase activitydefinition[GO:0061630]  
5
  • ParkinsonsUK-UCL
  • MGI
Ubiquitin protein ligase activity involved in ERAD pathwaydefinition[GO:1904264]  
3
  • ParkinsonsUK-UCL
Ubiquitin-specific protease bindingdefinition[GO:1990381]  
2
  • ParkinsonsUK-UCL
Unfolded protein bindingdefinition[GO:0051082]  
1
  • ParkinsonsUK-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968]  
1
  • RefGenome
ER-associated ubiquitin-dependent protein catabolic processdefinition[GO:0030433]  
7
  • ParkinsonsUK-UCL
  • UniProtKB
  • MGI
ERAD pathwaydefinition[GO:0036503]  
1
  • ParkinsonsUK-UCL
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902236]  
3
  • ParkinsonsUK-UCL
Protein K48-linked ubiquitinationdefinition[GO:0070936]  
1
  • ParkinsonsUK-UCL
Protein N-linked glycosylation via asparaginedefinition[GO:0018279]  
1
  • UniProtKB
Protein stabilizationdefinition[GO:0050821]  
1
  • ParkinsonsUK-UCL
Protein ubiquitinationdefinition[GO:0016567]  
3
  • ParkinsonsUK-UCL
Protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:0042787]  
3
  • ParkinsonsUK-UCL
Retrograde protein transport, ER to cytosoldefinition[GO:0030970]  
1
  • ParkinsonsUK-UCL
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Protein processing in endoplasmic reticulum  hsa04141+84447  
Ubiquitin mediated proteolysis  hsa04120+84447  
According to Reactome, this protein belongs to the following pathways:
ER Quality Control Compartment (ERQC)  R-HSA-901032  
Hedgehog ligand biogenesis  R-HSA-5358346  
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD  R-HSA-5362768  
XBP1(S) activates chaperone genes  R-HSA-381038  
 

Keywords

Biological process 
Stress response  definition   [KW-0346]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SYVN1
GenomeRNAi: 84447
PRO: PR:Q86TM6