SYVN1 - E3 ubiquitin-protein ligase synoviolin - human protein (Function)
 
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SYVN1 »  E3 ubiquitin-protein ligase synoviolin   [ EC 6.3.2.- ]
 
Protein also known as:  Synovial apoptosis inhibitor 1.
Gene name:  SYVN1
Family name: HRD1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 62 3
GENE REF ISO

Function

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Overview 
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.  
10
  • CuratedUniProtKB
GO molecular function 
Acid-amino acid ligase activitydefinition[GO:0016881]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIUniProtKB
  • IPIIntAct
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
ER-associated ubiquitin-dependent protein catabolic processdefinition[GO:0030433]  
2
  • IMPUniProtKB
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:1902236] silver  
  • IEAOrtholog Compara
Protein N-linked glycosylation via asparaginedefinition[GO:0018279]  
1
  • IMPUniProtKB
Protein ubiquitinationdefinition[GO:0016567]  
  • IEAUniPathway
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Protein processing in endoplasmic reticulum  hsa04141+84447  
Ubiquitin mediated proteolysis  hsa04120+84447  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Stress response  definition   [KW-0346]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SYVN1
GenomeRNAi: 84447
PRO: PR:Q86TM6