ABCA12 - ATP-binding cassette sub-family A member 12 - human protein (Function)
 
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ABCA12 »  ATP-binding cassette sub-family A member 12
 
Protein also known as:  ATP-binding cassette transporter 12 (ATP-binding cassette 12).
Gene name:  ABCA12
Family name: ABC transporter » ABCA
Entry whose protein(s) existence is based on evidence at protein level
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1 72 2
GENE REF ISO

Function

 show evidences
Overview 
Probable transporter involved in lipid homeostasis.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.211.13  
GO molecular function 
Apolipoprotein A-I receptor bindingdefinition[GO:0034191]  
1
  • BHF-UCL
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626]  
1
  • RefGenome
Cholesterol transporter activitydefinition[GO:0017127]  
1
  • RefGenome
Lipid transporter activitydefinition[GO:0005319]  
1
  • BHF-UCL
Lipid-transporting ATPase activitydefinition[GO:0034040]  
1
  • BHF-UCL
Phospholipid transporter activitydefinition[GO:0005548]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Receptor bindingdefinition[GO:0005102]  
1
  • BHF-UCL
GO biological process 
Cellular homeostasisdefinition[GO:0019725]  
1
  • UniProtKB
Ceramide transportdefinition[GO:0035627] silver  
1
  • Ortholog Compara
Cholesterol transportdefinition[GO:0030301]  
1
  • RefGenome
Establishment of skin barrierdefinition[GO:0061436] silver  
1
  • Ortholog Compara
Keratinizationdefinition[GO:0031424] silver  
1
  • Ortholog Compara
Lipid homeostasisdefinition[GO:0055088] silver  
1
  • Ortholog Compara
Lipid transportdefinition[GO:0006869]  
2
  • BHF-UCL
  • UniProtKB
Lung alveolus developmentdefinition[GO:0048286] silver  
1
  • Ortholog Compara
Metabolic processdefinition[GO:0008152]  
1
  • InterPro 2 GO
Phospholipid effluxdefinition[GO:0033700]  
1
  • BHF-UCL
Positive regulation of cholesterol effluxdefinition[GO:0010875]  
1
  • BHF-UCL
Positive regulation of protein localization to cell surfacedefinition[GO:2000010] silver  
1
  • Ortholog Compara
Protein localization to plasma membranedefinition[GO:0072659]  
2
  • BHF-UCL
Regulated secretory pathwaydefinition[GO:0045055]  
1
  • BHF-UCL
Secretion by celldefinition[GO:0032940]  
1
  • BHF-UCL
Surfactant homeostasisdefinition[GO:0043129] silver  
1
  • Ortholog Compara
Transmembrane transportdefinition[GO:0055085]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathway:
ABC transporters  hsa02010+26154  
According to Reactome, this protein belongs to the following pathway:
ABCA transporters in lipid homeostasis  REACT_111158  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCA12
GenomeRNAi: 26154
PRO: PR:Q86UK0