AGPAT6 - Glycerol-3-phosphate acyltransferase 4 - human protein (Function)
 
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References

 
AGPAT6 »  Glycerol-3-phosphate acyltransferase 4   [ EC 2.3.1.15 ]  (GPAT4)
 
Protein also known as:  Acyl-CoA:glycerol-3-phosphate acyltransferase 4.
Gene name:  AGPAT6
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.  
1
  • CuratedUniProtKB
GO molecular function 
Not  1-acylglycerol-3-phosphate O-acyltransferase activitydefinition[GO:0003841]  
1
  • IDAUniProtKB
Glycerol-3-phosphate O-acyltransferase activitydefinition[GO:0004366]  
1
  • IDAUniProtKB
GO biological process 
Acyl-CoA metabolic processdefinition[GO:0006637]  
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  • IDAUniProtKB
CDP-diacylglycerol biosynthetic processdefinition[GO:0016024]  
  • IEAUniPathway
Diacylglycerol metabolic processdefinition[GO:0046339] silver  
  • IEAOrtholog Compara
Fatty acid metabolic processdefinition[GO:0006631] silver  
  • IEAOrtholog Compara
Glandular epithelial cell maturationdefinition[GO:0002071] silver  
  • IEAOrtholog Compara
Lactationdefinition[GO:0007595]  
  • ISSOrtholog Curator
Lipid biosynthetic processdefinition[GO:0008610]  
  • ISSOrtholog Curator
Phosphatidylcholine biosynthetic processdefinition[GO:0006656]  
1
  • IDAUniProtKB
Regulation of multicellular organism growthdefinition[GO:0040014] silver  
  • IEAOrtholog Compara
Contradiction  Triglyceride biosynthetic processdefinition[GO:0019432]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.15: Acyl-CoA + sn-glycerol 3-phosphate CoA + 1-acyl-sn-glycerol 3-phosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by N-ethylmaleimide (NEM).  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycerolipid metabolism  hsa00561+137964  
Glycerophospholipid metabolism  hsa00564+137964  
Metabolic pathways  hsa01100+137964  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Phospholipid biosynthesis  definition   [KW-0594]
Phospholipid metabolism  definition   [KW-1208]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 137964
PRO: PR:Q86UL3